17 May 2023, 22:19 UTC≈1,280 viewsread 9 August 2026 5/17
Regulation of cytokinesis by Rho GTPase flux
Rho activation by guanine nucleotide exchange factors (GEFs) - initiation
Rho inactivation by GTPase activating proteins (GAPs) - termination
MgcRacGAP: a conserved cytokinesis regulator thought to be required only at the end of cytokinesis
This paper: GAP activity of MgcRacGAP is necessary early during cytokinesis for the formation and maintenance of the Rho activity…
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12 Apr 2023, 19:20 UTC≈1,200 viewsread 9 August 2026 4/12
Midblastula transition (MBT) of the cell cycles in the yolk and pigment granule-free translucent blastomeres obtained from centrifuged Xenopus embryos (Development, differentiation, and growth 2005 Japan)
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11 Apr 2023, 21:32 UTC≈1,010 viewsread 9 August 2026 Photo
4/11
A Model for Cleavage Plane Determination in Early Amphibian and Fish Embryos (Current Biology 2010 Tim Mitchison)
metaphase spindles are positioned and oriented by interactions of their astral microtubules with the cellular cortex, followed by cleavage in the plane of the metaphase plate
a model to explain cleavage plane geometry in which the length of astral microtubules is limited by interaction with these bou…
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11 Apr 2023, 21:07 UTC802 viewsread 9 August 2026 4/11
Nuclear Size Scaling during Xenopus Early Development Contributes to Midblastula Transition Timing (2015 Current biology University of Wyoming)
The N/C volume ratio increases prior to the MBT during Xenopus development
Nuclear size and the N/C volume ratio can be manipulated in Xenopus embryos
Altering the N/C volume ratio changes the timing of zygotic gene transcription
Altering the N/C volume ratio changes the…
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11 Apr 2023, 21:02 UTC677 viewsread 9 August 2026 4/11
Exploring generic principles of compartmentalization in a developmental in vitro model (2023 developments German)
protocell patterns emerge by simultaneous formation of randomly assembling protocells that grow at a uniform rate towards a frustrated arrangement before fusion of adjacent protocells eventually drives coarsening
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11 Apr 2023, 19:58 UTC620 viewsread 9 August 2026 Photo
4/11
Dynactin functions as both a dynamic tether and brake during dynein-driven motility (nature communication 2014 Upenn)
dynactin enhances the initial recruitment of dynein onto microtubules and promotes the sustained engagement of dynein with its cytoskeletal track
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11 Apr 2023, 19:40 UTC519 viewsread 9 August 2026 Photo
4/11
A Pushing Mechanism for Microtubule Aster Positioning in a Large Cell Type (Cell report 2020 Boston College David R. Burgess)
Chemical ablation of rear astral MTs halts aster migration
Inhibition of dynein-mediated transport increases aster migration rate
After sperm aster centration, the female pronucleus pulls by dynein on the aster
Sperm aster geometry and growth dynamics are consistent with pushing
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11 Apr 2023, 18:45 UTC441 viewsread 9 August 2026 4/11
Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles (JCB 2004 Tarun M. Kapoor Rockefeller)
dynein/dynactin: a multi-subunit microtubule minus-end–directed motor complex
NuMA:a microtubule cross-linker
Dynein/dynactin + NuMA - regulate the MT length
dynactin or NuMA inhibition suppresses microtubule disassembly at spindle poles without affecting polewards micr…
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21 Mar 2023, 19:46 UTC397 viewsread 9 August 2026 Photo
3/21
Reorganization of actin cytoskeleton at the growing end of the cleavage furrow of Xenopus egg during cytokinesis (JCB 2001)
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16 Mar 2023, 03:45 UTC376 viewsread 9 August 2026 3/15
Katanin Contributes to Interspecies Spindle Length Scaling in Xenopus (Cell 2011 Rebecca Heald)
Phosphation of AuroraB -> decrease the serving of katanin -> decrease MT depolymerization rate -> increase the spindle size
The balance of k-fiber number and MT depolymerization rate -> maintain the spindle morphology
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17 Feb 2023, 01:54 UTC367 viewsread 9 August 2026 2/16
Rapid evolution of protein diversity by de novo origination in Oryza (Nature Ecology & Evolution 2019 UChicago)
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23 Jan 2023, 06:52 UTC373 viewsread 9 August 2026 1/12
Importin α partitioning to the plasma membrane regulates intracellular scaling
These experiments identify importin α as a conserved surface area-to-volume sensor that scales intracellular structures to cell size.
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Showing the 12 most recent of 20 posts we hold for @PaperReading. View and reaction counts are the latest single reading for each post, not a live figure, and a recent post is still accumulating both. A view count marked ≈ was rounded by Telegram before we ever saw it — t.me prints views in full below 1,000 and to three significant figures above, so ≈1,200,000 means somewhere between 1,150,000 and 1,249,999. Unmarked counts are exact. Text is reproduced from the public post preview and truncated for length.